If a man's PSA has risen rapidly in recent years, there is no cause for concern if his total PSA level is still low and his clinical exam is normal.
He said the large study adds to others showing that changes in PSA should not be used alone as a basis for getting a biopsy. Besides cancer, other conditions, including an enlarged prostate and infections, can cause PSA levels to rise.
Once diagnosed, more than 90 percent of men with low-grade prostate cancer get treated, most often with surgery or radiation. Both can cause lasting side effects including impotence or incontinence.
